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KMID : 0603820070130040305
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Journal of Experimental & Biomedical Science
2007 Volume.13 No. 4 p.305 ~ p.311
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The Catalytic Subunit of Protein Kinase A Interacts with Testis-Brain RNA-Binding Protein (TB-RBP)
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Ju Hyun-Hee
Ghil Sung-Ho
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Abstract
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cAMP-dependent protein kinase A (PKA) is the best-characterized protein kinases and has served as a model of the structure and regulation of cAMP-binding protein as well as of protein kinases. To determine the function of PKA in development, we employed the yeast two-hybrid system to screen for catalytic subunit of PKA (Calpha) interacting partners in a cDNA library from mouse embryo. A Testis-brain RNA-binding protein (TB-RBP), specifically bound to Calpha. This interaction was verified by several biochemical analysis. Our findings indicate that Calpha can modulate nucleic acid binding proteins of TB-RBP and provide insights into the diverse role of PKA.
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KEYWORD
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TRAX, Development, Yeast two-hybrid
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